Macromolecole Biologiche
Lo scopo della Sezione AIC sulle Macromolecole Biologiche (BMM) è quello di favorire il progresso di tutti gli aspetti e le applicazioni delle tecniche cristallografiche e di microscopia elettronica in condizioni criogeniche alle proteine, agli acidi nucleici e ai loro complessi, promuovendo al contempo la comunicazione tra i membri dell’AIC attivi o interessati ai vari sviluppi in questi campi.
L’obiettivo del sito web BMM è quello di collegare i gruppi di biologia strutturale e di cristallografia in Italia alle principali infrastrutture europee, ai prossimi incontri scientifici e corsi, ai fornitori, alle opportunità di lavoro e ai pacchetti software specialistici o di uso generale. Miriamo anche a favorire la discussione e lo scambio di idee o materiali, e a promuovere la collaborazione tra i gruppi.
Nulla di questo genere accade senza il continuo e attento contributo della comunità, che è invitata a contribuire con notizie, idee, offerte, ecc. Ciò è particolarmente prezioso in Italia, dove i gruppi di biologia strutturale sono dislocati in Dipartimenti e ambiti scientifici molto diversi, e possono essere relativamente sottodimensionati. Miriamo ad aiutare tutti attraverso queste pagine e il flusso di informazioni ad esse associate.
Tutti i suggerimenti costruttivi per migliorare la nostra comunicazione sono ben accetti. Fateci sapere cosa vorreste vedere in queste pagine, aspettiamo il vostro contributo!
Coordination Board
Stefano Mangani – stefano.mangani@unisi.it – Coordinatore
Rocco Caliandro – rocco.caliandro@cnr.it – editor di contenuti web
Andrea Ilari – andrea.ilari@cnr.it
Marina Mapelli – marina.mapelli@ieo.it
BMM Research groups
| Protein crystallography and cryoEM Department of Biomedical Sciences, University of Padua Giuseppe Zanotti, Tito Calì, Paola Berto, Francesca Vallese, Alessandro Grinzato. |
| Structural Biology group Department of Biology and Biotechnology, University of Pavia Andrea Mattevi, Claudia Binda, Federico Forneris, Francesca Magnani, Stefano Rovida. |
| Biomolecular Structures, Macromolecular Crystallography Department of Chemical Sciences, University of Padua Roberto Battistutta, Elisa Costanzi, Valentina Furlanetto. |
| Laboratory of Protein Crystallography and Structure-Based Drug Design CIBIO – Centre for Integrative Biology, University of Trento Graziano Lolli, Giulia Cazzanelli, Andrea Dalle Vedove. |
| Methods, X-ray diffraction and bioSAXS CNR – Institute of Crystallography, Bari Giovanni Luca Cascarano, Rocco Caliandro, Dritan Siliqi, Benedetta Carrozzini, Danilo Benny Belviso, Davide Altamura, Cinzia Giannini. PDB: 6QUF and 6QUK. Protein crystallizatino by ionic liquid hydrogel support PDB: 6FSW Structure of Archaeoglobus fulgidus SBDS protein at 1.9 Angstrom PDB: 5H6Z and 5WW0, Crystal structure of Set7, a novel histone methyltransferaase in Schizossacharomyces pombe PDB: 5TZL, Pt(II)-mediated copper-dependent interactions between ATOX1 and MNK1 SASBDB: SASDET8, GTPase Elongation Factor like-1 bound Shwachman-Diamond Syndrome protein (EFL1*SDo1) SASBDB: SASDAC8, SDS hydrolase SdsA1 SASBDB: SASDEV8, Shwachman-Diamond Syndrome protein (yeast SD01) SASBDB: SASDEW8, Shwachman-Diamond Syndrome protein (SD01) with domains 2 and 3 SASBDB: SASDEU8, GTPase Elongation Factor like-1 protein (yeast EFL1) |
| Department of Biosciences, University of Milan Martino Bolognesi, Martina Palamini, Paolo Swuec, Delia Tarantino. Carlo Camilloni, Cristina Paissoni. Louise-Gourlay, Stefano De Benedetti, Flavio Di Pisa. Marco Nardini, Antonio Chaves Sanjuan, Michela Lapi. Stefano Ricagno, Rosaria Russo, Cristina Visentin, Luca Oberti, Luca Broggini. |
| CNR – The Biophysics Institute, Milano Mario Milani, Eloise Mastrangelo, Michela Bollati, Francesco Boni, Federica Cossu, Matteo De Rosa. |
| CERM Department of Chemistry “Ugo Schiff”, University of Florence Vito Calderone. |
| IIT, Center for Nano Science and Technology, Milano Emilio Parisini, Stefano Donini, Tommano Prosdocimi, Chiara Vettraino, Arthimede Torretta, Sara Abbate. |
| Laboratory of Protein Crystallography and BioXAS. PX for drug discovery Department of Biotechnology, Chemistry and Pharmacy, University of Siena Stefano Mangani, Cecilia Pozzi, Manuela Benvenuti, Giusy Tassone, Federica Carucci, Ludovica Lopresti. |
| Biocrystallography and Biomineralization group Dipartiment of Chemistry “Giacomo Ciamician”, University of Bologna Giuseppe Falini, SImona Fermani, Giulia Magnabosco, Devis Montroni, Francesco Lanero, Veronica Bissi, Andrea Condorelli. PDB: 6H7G, Crystal structure of redox-sensitive phosphoribulokinase (PRK) from the green algae Chlamydomonas reinhardtii PDB: 6H7H, Crystal structure of redox-sensitive phosphoribulokinase (PRK) from Arabidopsis thaliana PDB: 6Q46, 6Q47, Crystal structure of thioredoxin h1 from Chlamydomonas reinhardtii PDB: 6Q6T, 6Q6U, 6Q6V, Crystal structure of C39S mutant of thioredoxin h1 from Chlamydomonas reinhardtii PDB: 6I19, Crystal structure of Chlamydomonas reinhardtii thioredoxin h1 PDB: 6I1C, Crystal structure of Chlamydomonas reinhardtii thioredoxin f2 PDB: 5ND5, 5ND6, Crystal structure of apo transketolase from Chlamydomonas reinhardtii PDB: 5NLF, 5NLI, 5NMC, 5NL4, 5NL5, 5NLJ, Crystal structure of Zn3-hUb(human ubiquitin) adduct |
| Structural Biology Group CNR – Institute of Crystallography, Trieste Doriano Lamba, Sonia Covaceuszach, Alessandro Pesaresi, Alberto Cassetta. |
| BioStructures Lab Istituto Italiano di Tecnologia, CNI@NEST, Pisa Ganpiero Garau, Eleonora Margheritis, Valentina De Lorenzi, Sara Chiarugi, Elisa Martino. |
| Integrated Structural Biology Lab Istituto Europeo di Oncologia, Milano Marina Mapelli, Sebastiano Pasqualato, Valentina Cecatiello, Danilo Faccenda, Chiara Gaddoni, Silvia Monzani, Valentina Palmerini, Laura Pirovano, Cristina Renna, Francesca Rizzelli. |
| Bioorganic Chemistry and Bio-Crystallography laboratory (B2Cl) Faculty of Science and Technology, Free University of Bozen Stefano Benini, Rosanna Caliandro, Ivan Polsinelli. PDB: 6FRW, X-ray structure of the levansucrase from Erwinia tasmaniensis PDB: 5O8P, The crystal structure of DfoA bound to FAD, the desferrioxamine biosynthetic pathway cadaverine monooxygenase from the fire blight disease pathogen Erwinia amylovora PDB: 5O3Z, Crystal structure of Sorbitol-6-Phosphate 2-dehydrogenase SrlD from Erwinia amylovora PDB: 5O5C, The crystal structure of DfoJ, the desferrioxamine biosynthetic pathway lysine decarboxylase from the fire blight disease pathogen Erwinia amylovora PDB: 5O7O, The crystal structure of DfoC, the desferrioxamine biosynthetic pathway acetyltransferase/Non-Ribosomal Peptide Synthetase (NRPS)-Independent Siderophore (NIS) from the fire blight disease pathogen Erwinia amylovora PDB: 5O8R, The crystal structure of DfoA bound to FAD and NADP; the desferrioxamine biosynthetic pathway cadaverine monooxygenase from the fire blight disease pathogen Erwinia amylovora PDB: 5FRK, SeMet crystal structure of Erwinia amylovora AmyR amylovoran repressor, a member of the YbjN protein family PDB: 5FR7, Erwinia amylovora AmyR amylovoran repressor, a member of the YbjN protein family |
| Biocrystal facility of Roma CNR-Institute of Molecular Biology and Pathology and Department of Biochemical Sciences, Sapienza University of Roma Adele di Matteo, Giorgio Giardina, Annarita Fiorillo, Andrea Ilari, Linda Celeste Montemiglio, Linda Savino, Beatrice Vallone, |
| Structural Biology group Department of Pharmaceutical Sciences, University of Piemonte Orientale, Novara Menico Rizzi, Davide Maria Ferraris, Silvia Garavaglia, Riccardo Miggiano, Franca Rossi. PDB: 5MP7, Crystal structure of phosphoribosylpyrophosphate synthetase from Mycobacterium smegmatis PDB: 5HKF, Crystal structure of Mycobacterium tuberculosis H37Rv orotate phosphoribosyltransferase in complex with 5-phospho-alpha-D-ribosyl 1-diphosphate (PRPP) PDB: 5LLQ, Crystal structure of Sulfolobus solfataricus O6-methylguanine methyltransferase C119F variant PDB: 5FHZ, Human aldehyde dehydrogenase 1A3 complexed with NAD(+) and retinoic acid |
| Laboratory of Structural Biology University of L’Aquila, L’Aquila Francesco Angelucci, Rodolfo Ippoliti, Francesco Giansanti, Matteo Ardini, Luana Di Leandro, Silvestri Ilaria, Francesca Fata, |
| Gruppo di strutture di biomacromolecole CNR, Istituto di Biostrutture e Bioimmagini Rita Berisio, Alessia Ruggiero, Flavia Squeglia, Maria Romano PhD students: Eliza Kramarska, Giovanni Barra Main PDB structures: 3NE0, 5E27, 4Q4G, 4Q4N, 4JMN, 2MGV, 4KL7, 4JMX,4KPM, 4EMN, 3EO5, 4KQT, Structures of cell division proteins of M. tuberculosis 6TKU, 8BKE, Structures of phage origin capsule depolymerases active against Klebsiella pneumoniae 4OKJ, 4OKK, 6S0M, 4OKE, Structures of the RNaseAS, a key virulence factor of M. tuberculosis 1Z58, 1OND, 1NJP, 1NJM, 1NJN, 1NJO, 1P9X, Structures of the 50S large ribosomal subunit in complex with antibiotics 2Z4U, 2Z53, 2QES, 2QET, 3H5K, 3LE7, Structures of plant ribosome inactivating proteins 6GPD, 6GPM, 6GGP, Structures of solute binding proteins ArgBP 1K6F, 1G9W, Structures of collagen triple helix models |
| Structural Biology of Biomolecules (Synthetic Biology and Biotechnology research unit) Department of Biology, University of Padova Laura Cendron; PhD students: Sofia De Felice, Monica Chinellato; Postdoc: Filippo Vascon; Graduate fellow: Angela Pavan; Marie-Curie Fellow (co-hosting Institution): Antonella Pasquato Recent structures: 7OCJ, 7ZRA, 7B5G: Structure of LexA repressor in complex with Nanobody-based inihibitors 8A76, 6TGI, 6TGD, 6IBV, 6IBS etc: Metallo b-lactamases (VIM-2, NDM-1) in complex with inhibitors 7Z57, 7QFE, 7AAE, 7AAI: study of albumin in complex with drugs and perfluoroalkyl pollutants 6T7H, 6GWE: Thrombin in complex with Macrocycle Inhibitors |
| Gruppo di Biostrutture Dipartimento di Scienze Chimiche, Università di Napoli Federico II Filomena Sica, Antonello Merlino, Giarita Ferraro; Post-Doc: Romualdo Troisi; PhD students: Maddalena Paolillo, Gabriella Tito Main PDB structures: 3QLP, 4DIH, 4DII, 4I7Y, 4LZ1, 4LZ4, 5CMX, 5EW1, 5EW2, 6EVV, 6GN7, 6Z8V, 6Z8W, 6Z8X, 7NTU, 7ZKL, 7ZKM, 7ZKN, 7ZKO, 8BW5 X-ray structure of the complexes between human thrombin and DNA aptamers. 8C62, 8C63, 8C64, 8CE2 Crystal structures of the adducts between B-DNA and metal compounds. 4RSZ, 4S1Y, 5JLG, 5L4R, 5N26, 6ENW, 6RJV, 7NPM, 7NQB, 8BRC Crystal structures of the adducts between proteins and metal compounds. 3LIO, 3LJ9, 3LJF, 4L2A, 4L2B, 4L2C, 4L2D, 4YIO, 4YIP X-ray structure of superoxide dismutases. 3BCM, 3BCO, 3BCP, 3FKZ, 3FL0, 3FL1, 3FL3, 3F8G, 3LJD, 3LJE, 3LN8, 3RH1, 3RID, 4N4C, 4KXH, 7BFK, 7BFL Crystal structures of ribonucleases. 1YV4, 1YV6, 1YV7 Crystal structures of onconases. 4L0A X-ray structure of an all LNA quadruplex. 1KF2, 1KF3, 1KF4, 1KF5, 1KF7, 1KF8, 4IAU,1DY5 Atomic resolution protein structures. 1R37, 1NTO, 1NGV, 1JNG, 1JVB, 1SKQ Structures of enzymes from extremophilic microorganisms. 2P1X, 4Y23, 5O7R, 6Y3D, 6FF5, 8B4N Crystal structures of other proteins. |
